Advertisement

Diet Rich In Fat, Sugar Connected To Skin Inflammation

Psoriasis is a common chronic skin condition that generates scales and red patches of skin that are irritating and occasionally painful. Obesity is a risk factor for the onset or progression of psoriasis, according to earlier research.

According to a study by UC Davis Health researchers, inflammatory skin conditions like psoriasis may be brought on by a Western diet high in fat and sugar.

According to the study, which was written up in the Journal of Investigative Dermatology, dietary factors rather than obesity itself may be responsible for skin inflammation and the onset of psoriasis. 

Psoriasis is a common chronic skin condition that generates scales and red patches of skin that are irritating and occasionally painful.

Obesity is a risk factor for the onset or progression of psoriasis, according to earlier research. The rising incidence of obesity around the world has been attributed to the Western diet, which is characterised by a high dietary consumption of saturated fats and sugar and a low intake of fibre.

"In our study, we found that short-term exposure to Western diet is able to induce psoriasis before significant body weight gain," said Sam T. Hwang, professor and chair of dermatology at UC Davis and senior author on the study.

For the UC Davis Health study, which used a mouse model, Hwang and his colleagues found that a diet containing both high fat and high sugar (mimicking the Western diet in human) was required to induce observable skin inflammation. In four weeks only, mice on Western diet had significantly increased ear swelling and visible dermatitis compared to mice fed a controlled diet and those on high fat diet alone.

"Eating an unhealthy diet does not affect your waistline alone, but your skin immunity too," said Zhenrui Shi, visiting assistant researcher in UC Davis Department of Dermatology and lead author on the study.

The study detailed the mechanisms by which inflammation happens following a Western diet. It identified bile acids as key signaling molecules in the regulation of skin immunity. Bile acids are produced in the liver from cholesterol and metabolized in the intestine by the gut microbiota. They play an important role in dietary lipid absorption and cholesterol balance in the blood.

The study found that cholestyramine, a drug used to lower cholesterol levels by binding to bile acids in the intestine, helped reduce the risk of skin inflammation. The finding suggests that bile acids mediate the development of psoriasis. The binding of cholestyramine to bile acids in the gut and its subsequent release through the stool allows for lowering of skin inflammation. (ANI)




Tags assigned to this article:
healthcare obesity inflammation Skin

Advertisement

Around The World

Recent

Mpower Debuts In Delhi Pioneering Multidisciplinary Mental Health Services

Present at the launch Dr. Neerja Birla unveiled suicide prevention toolkit to combat the alarming rise of suicides in India ...

Ankush Bhandari Joins Alight Solutions As VP, Country Leader Of Health & Insurance Solutions

Alight is a cloud-based human capital technology and services provider that powers confident health, wealth and well-being decisions for 36 million pe...

Scientists Recreate Neurons That Allow Mice To Walk Again After Injury

In a study on mice, a group of researchers identified a crucial element for recovering functional activity following spinal cord injury...

Cough Sound Analysis Assists In Determining Severity Of Covid-19 Patients

Some of those infected may develop more severe illness and pneumonia, resulting in a more bleak outlook...

Understanding Brain Strokes: Types, Causes And Warning Signs

A stroke occurs when the blood supply to a part of the brain is disrupted, leading to a variety of debilitating consequences...

Cardiovascular Health Across Different Age Groups

Cardiovascular disease (CVD) has emerged as a global health challenge, with far-reaching consequences for individuals and nations alike ...


Quick Connect With BW Wellness

Subscribe Our Newsletter