Trial Drug Fails To Have Any Effect On Alzheimer's: Report

Roche report says, injected drug had no significant effect on the symptoms of Alzheimer's or on a protein called amyloid responsible for the disease

Around 55 million people worldwide have some form of dementia, with alzheimer's being the most common. Unfortunately, there is no cure for this memory-depriving disease, but a lot of people's hopes were pinned on an experimental drug named Gentanerumab.

A recent report by the drug maker Roche said that the injected drug had no significant effect on the symptoms of Alzheimer's or on a protein called amyloid responsible for the disease.

Gentanerumab is an antibody that attaches itself to amyloid. On the other hand, amyloid is a sticky protein that keeps accumulating in the brains of people suffering from Alzheimer's. As soon as this antibody binds to Amyloid, the brain's natural defense system is triggered, which removes Amyloid.

Smaller trials of gantenorumab supported this view because it had a positive effect on the symptoms of the disease and reduced Amyloid clusters. But its trials on a large scale failed to replicate the initial success, which once again raises questions about targeting Amyloid. The causes of Alzheimer's disease are not yet known, but the most popular explanation is the so-called "Amyloid cascade hypothesis".

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Alzheimer's Dementia roche


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