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Stiff Person Syndrome: Know Symptoms And Treatment

Stiff Person Syndrome is an autoimmune disease and mainly affects the trunkal muscles and causes severe back pain

Nowadays, people are going through several diseases due to a bad lifestyle. Stiff person syndrome is a very rare autoimmune disorder. It is also known as Moersch Woltman syndrome.

It is an autoimmune disease and mainly affects the trunkal muscles and causes severe back pain, spasms and impaired mobility. Painful spasms are triggered by various stimulii such as touch, sound, emotional stress or fast movements.The stiffness leads to change in posture and patient develops a rigid gait.

Back muscles followed by abdominal muscles than proximal limb muscles and rarely facial muscles are also involved.The sudden spasms are extremely painful.

Patients have increased GAD (glutamic acid decarboxylase) antibodies in their blood. Some patients may have antibodies against amphysin and gephyrin. These cause decrease in the level of inhibitory neuro transmitter GABA. This reduction in GABA causes stiffness and spasm of muscle.

As it is an autoimmune disease it may be treated with immunosuppressive therapies along with treatment for symptoms like muscle relaxant and pain killers.

Long term impact on the body over years may lead to change in gait posture and sometimes severe spasms may cause bone fractures.

It is commonly seen in females more than males (3:2) and also associated with autoimmune disease like pernicious anaemia, thyoidiits, vitiligo and diabetes. It may an immune mediated paraneoplastic syndrome associated in some cancers.

Overall it is a rare disease and only a high level of suspicion helps diagnose this condition.



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